Benefits
Calm Biotect™ supports healthy stress levels, healthy sleep, and a relaxed, calm mind. Brain health-supporting amino acids are combined with a blend of organic botanical extracts, including valerian, chamomile, passionflower, and ashwagandha, that work synergistically to aid brain health and emotional well-being. Research suggests these ingredients interact with neurotransmission in the brain to promote calmness, relaxation and sleep.
Bottle contains 120 capsules (60-day supply)
Caution: If you are pregnant, nursing, or on medication, consult with your healthcare practitioner.
- Promotes relaxation and a calm mind
- Promotes restful sleep
- Calming organic botanical extracts: ashwagandha, valerian, passionflower, and chamomile
- Amino acid L-tryptophan used by the body to produce melatonin and serotonin
- Vegan; does not contain gluten, dairy, or GMOs
- Manufactured by a GMP certified and FDA-regulated facility
Key Ingredients
L-Tryptophan
Tryptophan is an amino acid that is converted to serotonin and melatonin in the brain, hormones that play important roles in regulating our mood and sleep, respectively.
L-theanine
L-theanine is an amino acid naturally occurring in tea; the highest concentration is found in green tea, where L-theanine makes up about 1-2 percent of the dry weight of green tea leaves. Research suggests L-theanine is helpful to reduce stress and induce relaxation.
GABA
GABA (gamma-aminobutyric acid) is a non-protein amino acid and neurotransmitter that is an important regulator of sleep, circadian rhythms, and stress. GABA is present in some natural foods, such as soybeans, fermented foods, tea, and adzuki beans, and supplemental GABA has been demonstrated to have stress-reducing properties.
Phosphatidylserine
Phosphatidylserine is a major phospholipid in brain cell membranes, important for cell signaling and neurotransmitter release.
Ashwagandha
Ashwagandha (Withania somnifera) is an herb traditionally used in Ayurveda that has antioxidant and anti-inflammatory effects, and studies and clinical evidence report reductions in stress. We use organic ashwagandha in Calm Biotect
Organic botanical blend
Passionflower, a purple-flowered vine native to the Southeastern United States, has been linked to quality sleep and healthy stress levels. Several randomized controlled trials on valerian have reported improvements in sleep duration or sleep quality, or reductions in stress. Chamomile tea, rich in phytochemicals including the flavonoid apigenin, has long been thought to have calming effects, and recent studies on chamomile supplementation support this. In animal studies, L-theanine and phytochemicals from passionflower, valerian, and chamomile affect levels of the neurotransmitter GABA, and they are thought to promote relaxation and sleep through GABA.
Frequently Asked Questions
Can I take Calm Biotect™ to help me manage stress during the day, or only at bedtime?
Yes, you can take it during the day, or at bedtime.
Is Calm Biotect™ gluten-free? Allergen-free?
The phosphatidylserine in Calm Biotect is derived from soy. Calm Biotect does not contain wheat, gluten, dairy, peanuts, tree nuts, fish, shellfish, or sesame. Calm Biotect is not manufactured in an allergen-free or gluten-free facility. Our manufacturing facility has an allergen control program in place designed to properly handle, store and use materials in production to eliminate the risk of cross-contamination, in accordance with Good Manufacturing Practices (GMPs).
What research went into this product?
Below are the studies that informed the development of this product:
1. Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients 2016, 8.
2. White DJ, de Klerk S, Woods W, et al. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients 2016, 8.
3. Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol 2007, 74:39-45.
4. Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Front Neurosci 2020, 14:923.
5. Kim HY, Huang BX, Spector AA. Phosphatidylserine in the brain: metabolism and function. Prog Lipid Res 2014, 56:1-18.
6. Pratte MA, Nanavati KB, Young V, Morley CP. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med 2014, 20:901-908.
7. Akhondzadeh S, Naghavi HR, Vazirian M, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001, 26:363-367.
8. Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007:CD004518.
9. Movafegh A, Alizadeh R, Hajimohamadi F, et al. Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Anesth Analg 2008, 106:1728-1732.
10. Shinjyo N, Waddell G, Green J. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis. J Evid Based Integr Med 2020, 25:2515690X20967323.
11. Adib-Hajbaghery M, Mousavi SN. The effects of chamomile extract on sleep quality among elderly people: A clinical trial. Complement Ther Med 2017, 35:109-114.
12. Amsterdam JD, Li Y, Soeller I, et al. A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol 2009, 29:378-382.
13. Keefe JR, Guo W, Li QS, et al. An exploratory study of salivary cortisol changes during chamomile extract therapy of moderate to severe generalized anxiety disorder. J Psychiatr Res 2018, 96:189-195.
14. Mao JJ, Xie SX, Keefe JR, et al. Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial. Phytomedicine 2016, 23:1735-1742.
15. Savage K, Firth J, Stough C, Sarris J. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Phytother Res 2018, 32:3-18.
16. Lardner AL. Neurobiological effects of the green tea constituent theanine and its potential role in the treatment of psychiatric and neurodegenerative disorders. Nutr Neurosci 2014, 17:145-155.
